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Third, in-depth investigation into pharmacokinetics and safety profiles is essential

Copper peptides are small, naturally occurring protein fragments that have a high affinity for copper ions, which are critical to normal body function

BBB breakdown can lead to neurotoxic accumulations of fibrin, thrombin, and plasmin, and red blood cell extravasation, the release of hemoglobin and ferrous iron, causing reactive oxygen species (ROS), which can all injure dopaminergic neurons [513]

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This increase was observed in both epithelial cells (PCK + PD-L1+) and stromal cells (DAPI + PD-L1 + PCK- in stromal compartment) (Supplementary Figure S7C)