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3 Future direction Non-pharmacological treatments are still exploratory, with certain limitations and areas requiring further investigation

High TPMT activity causes a universal increase in the different phosphorylated forms of the methylated metabolites, which have contrasting actions (Karim et al., 2013)

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Following 24 h incubation, cell viability was measured using the MTT assay

Improves Insulin Sensitivity Research supports that excessive free radicals may play a central role in causing insulin resistance, diabetes, and heart disease, as oxidative stress affects insulin production and the maintenance of blood sugar levels, which leads to diabetes