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Extensive animal and human studies have been conducted on medicinal preparations of A

Nevertheless, although cells transfected with a human metallothionein gene can acquire resistance to cisplatin and alkylating agents (Kelley et al, 1988), and cells that do not produce metallothionein show increased chemosensitivity (Kondo et al, 1995), there is no in vivo evidence to support a major role for metallothioneins in clinical drug resistance

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The GLO-1 promoter region contains multiple regulatory elements that allow transcription factors like AP-2, AP-1, Nrf2, E2F4, and NF-B to enhance its activity, leading to increased GLO-1 expression