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Decreased Inflammation : Adipose tissue (body fat) produces inflammatory cytokines that contribute to systemic inflammation

When you swallow a B12 pill, several steps have to work for it to be absorbed: stomach acid and the enzyme pepsin must release B12 from food or the supplement, the stomach must secrete a protein called intrinsic factor that binds to B12, and the B12-intrinsic factor complex must reach the ileum (the end of the small intestine) where it is finally absorbed

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generally, if its close to the next dose, skip the missed dose (do not double up doses)