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However, available evidence did not acknowledge that GPX1 SNP rs1050450 plays an important role in chronic kidney disease (CKD) progression or renal allograft dysfunction [53, 54]

Therefore, in GLP-1R KO mice, compensation mechanisms of other receptors may exist to balance the cAMP-mediated downstream signaling pathway to maintain normal survival and activities of the GLP-1R KO mice

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