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Early research suggested that glucose could directly stimulate excessive ROS production (Rizwan et al., 2020), including the activation of NADPH oxidase (Jansen et al., 2013), NO synthase uncoupling (Sasaki et al., 2008), and the stimulation of xanthine oxidase (Hernandez-Hernandez et al., 2022)

Fraser A, Harris R, Sattar N, Ebrahim S, Smith GD, Lawlor DA

Eriksson, C

Human arterial endothelial cell detachment in vitro : Its promotion by homocysteine and cysteine

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