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A key protective mechanism involves the oxidation of redox-sensitive cysteine residues on Keap1 notably Cys151, Cys273, and Cys288

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Herxheimer reactions however continued the days on IV ceftriaxone, despite trying to pulse the IV medication 4 days in a row per week, so she was subsequently taken off this protocol, and switched to IV doxycycline 200 milligrams per day, infused over a 2 hour time period along with Plaquenil, nystatin, and rifampin 300 milligrams PO BID

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