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Although, zopolrestat and tolrestat were discontinued due to severe hepatotoxicity and an unfavorable risk-benefit profile observed in phase 2 and phase 3 clinical trials, respectively [150152], and ranirestat, which also progressed through phase 3 trial, focused primarily on diabetic polyneuropathy rather than cardiovascular outcomes [153]

CB2 receptor antibody signal specificity: correlations with the use of partial CB2-knockout mice and anti-rat CB2 receptor antibodies

Appropriate model assumptions facilitated initial model reduction by capturing only the essential elements of the system

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Glutamine supplies critical intermediates needed for energy production and nucleotide synthesis while maintaining redox balance which together support strong immune responses