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Zhang S, Jiang C, Han G, Hao, D, Lian J, Liu Y, Zhang R, McIntosh J, Wang R, Dang M, Dai E, Wang Y, Santos D, Dadillo M, Leeming A, Chen Z, Hartig K, Bigcal J, Zhou J, Kanagal-Shamanna R, OK CY, Lee H, Steiner RE, Zhang J, Song X, Nair R, Ahmed S, Rodriquiez A, Thirumurthi S, Jain P, Wagner-Bartack N, Hill H, Nomie K, Flowers C, Futreal A, Wang L, and Wang M

However, the overreacted inflammatory response and ROS release could lead to cell death, and thus, the regulation of the inflammatory reaction and clearance of over-expressed ROS should be on demand for cartilage regeneration

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doi: 10.3389/fphar.2025.1510275 Received 25 October 2024 Accepted 28 April 2025 Published 12 May 2025 Volume 16 - 2025 Edited by Eliot Ohlstein, Drexel University School of Medicine, United States Reviewed by Valentina Vellecco, University of Naples Federico II, Italy Eugenia Piragine, University of Pisa, Italy Updates Copyright 2025 Zhu, Zhao, Lu, Zhang, Meng, Su, Chen, Xu, Sun and Nie