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ATF4 associates with amino acid response elements (AARE) and promotes the transcription of genes related to amino acid metabolism and stress response, in particular SLC7A11, thereby enabling cells to cope with amino acid-limited conditions (Koppula et al., 2021b)

210 Importantly, a brain-healthy diet avoids the reduction in neuroplasticity caused by a high-calorie or high-saturated fat/high-sugar diet, which promote neuroinflammation and oxidative stress, adversely affect the size and function of a critical brain region known as the hippocampus, and are associated with cognitive and mood disorders

Occurrence mechanism of ferroptosis Ferroptosis is a result of cellular metabolism and an imbalance in redox homeostasis (Fig