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The cytosolic mtDNA can then act as a potent DAMP, activating innate immune pathways and sustaining chronic neuroinflammatory signaling in disorders such as AD, PD and HD

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As previously mentioned, cancer cachexia is a syndrome that alters the patients functional status and is characterized by loss of body fat, muscle mass, appetite and systemic inflammation

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The recommendation that novel therapeutics have both grounding in patient datasets and thorough validation prior to being pursued in human patients may be one of the first steps toward the efficient clinical application of these targets [209, 210]