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Concurrently, EV-QuerCar elevated HES1 expression (Notch signaling) by 1.9-fold and 3.4-fold compared to NC and UV group, respectively (Fig

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Collectively, the existing evidence indicates that multiple oncogenic signaling pathways, such as c-Myc, Kras, and HIF-1, directly regulate key processes in glutamine metabolism, thereby driving the tumor dependence on glutamine