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It has to be considered that significant decreases in surgical margin length occur following excision and subgross evaluation of tumour-free margins overestimates the actual (histologic) tumour-free margins (Terry et al., 2017), while shrinkage of FISS volume following excision and formalin fixation seems to be negligible (Terry et al., 2016)

Mirpuri E, Garca-Trevijano ER, Castilla-Cortazar I et al (2002) Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-I