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thus, lactate exerts its function both as a metabolite and as an epigenetic modifier, mainly promoting the post-translational modification of lysine residues of histones and thus inducing the expression of genes associated with an immunosuppressive function of macrophages [ 44 and references therein]

10.1038/nature09472 17 WenM.ChenQ.ChenW.YangJ.ZhouX

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Furthermore, KO mice on WTD showed elevated cartilage protein levels of MMP-2 , MMP-9 , and MMP-13

Cells that express the marker gene can be isolated using flow cytometry based cell sorting