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The doses discussed in community frameworks are extrapolated from rat studies using standard body weight conversion formulas

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La dure thorique de ces rserves a t calcule sur la moyenne des pertes quotidiennes par excrtion biliaire, elles-mmes estimes entre 0,1 et 0,2 % des rserves totales (en tenant compte d'une rabsorption entro-hpatique elle-mme estime 50 %), partir de trs rares donnes obtenues par expriences aprs cholcystectomie [37]

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