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The final crucial parameter is the ratio between the two species, i.e

Instead, our findings demonstrate an important role for GSH in the liver, where under resting conditions, GSH maintains low NRF2 activity to permit ample expression of lipogenic enzymes, promotes the production of triglycerides, and sustains lipid abundance in vivo

However, Grx2 overexpression leads to the phosphorylation and activation of DRP1, restoring mitochondrial morphology and the mitochondrial GSH pool [27]

Regional development of glutamate dehydrogenase in the rat brain

Experimental materials Commercial reagents and antioxidants were purchased from Sigma-Aldrich (MA, USA)