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In the context of the full-length enzyme elucidated here, the SAM-mediated conformational change creates a central filament stalk composed of repeating units of the SAM-bound RD dimer, arranged in an antiparallel daisy-chain like fashion due to the interactions of the loop 516525 with the neighbouring subunit (Fig

Rojas-Charry L, Nardi L, Methner A, Schmeier MJ (2020) Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders

Its active ingredient, hydroxycitric acid (HCA), is believed to help suppress appetite and inhibit fat production

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