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This effect is likely due to the role B12 and other B vitamins play in metabolizing macronutrients like fats, carbohydrates, and proteins

Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha

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9.2.2.2 Innovations and applications of bioactive hydrogels Drug and growth factor delivery: Ligorio et al

Wound healing capacity in different tissues [1,2,1017] (including blood vessels) (i.e., stimulation of the early growth response 1 (egr-1) gene and its co-repressor nerve growth factor 1-A binding protein-2 (naB2) [17] also responsible for cytokine and growth factor generation and thereby, early extracellular matrix (collagen) and blood vessel formation [17]) and endothelium protection [1,2,14,15] were implicated in these counteracting effects