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Notably, a small cell lung carcinoma cell line, which expresses POMC and ACTH, possesses a hypomethylated POMC promoter, suggesting that ectopic ACTH secretion by tumors may be due to hypomethylation at a relatively early stage in carcinogenesis (41)

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On the other hand, some treatments, like RevA, BB0689, rOspA , OspA-Ferritin, lipidated rOspA, CspZ-VLP, and OspA mRNA-LMP, did not show any significant effects