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Despite not reaching statistical significance in the primary analysis ( p = 0.0987), the placebo-adjusted improvement in RV of 0.323 l did exceed the 0.3 l minimal clinically important difference [34], underscoring that a clinically meaningful outcome for this patient population was observed

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Proteomic analysis of EVs offers a highly promising avenue for the discovery of novel biomarkers for AD, poised to revolutionize early diagnosis, treatment monitoring, and precision medicine in the field of neurodegenerative disorders

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Conclusion Current research on DPN biomarkers encompasses a diverse array of candidates, including oxidative stress mediators, neural injury proteins, inflammatory cytokines, vascular dysfunction markers, metabolic intermediates, and genetic/epigenetic regulators