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Modulating eryptosis, whether by inducing or inhibiting the process, could help regulate erythrocyte survival to prevent premature cell loss or promote the removal of damaged erythrocytes, thereby contributing to the proper balance of blood cell counts

However, the mechanism of metabolic dysregulation in affecting the progress and disease severity of SCD has not been well characterized, especially when exposed to excess hemin

Statistical analysis All statistical analysis was completed using either R or GraphPad Prism (v.10.6.1)

doi: 10.1016/j.lfs.2005.01.015

In the critical redox system of mammalian cells, glutathione peroxidase (GPX) is the most prominent family of proteins with a multifaceted function that affects almost all cellular processes