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Moreover, Fauvet et al

[0596] Pharmaceutical compositions of the present invention may be administered in a manner appropriate to the disease to be treated (or prevented)

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However, FOXO4-DRI treatment significantly reduced the expression of these detrimental SASP factors and, critically, restored the proliferation of GC-1 spg cells in the co-culture system, as evidenced by CCK-8 assays and PCNA expression, without inducing apoptosis in the spermatogonia