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Therefore, the goal of studying SNP is a better understanding of inter-individual pharmacologic variation due to polymorphism of ABCB1, which may open a window for individualized therapy based on the patients ABC transporter genotype ( ABCB1 inhibitors Competitive inhibitors of ABCB1 are categorized into three generations of drugs based on pharmacodynamics characteristics ( Table 2 )

Finally, the gene-protein-reaction (GPR) associations were manually added to each reaction based on the enzyme subunit and isoenzyme information obtained from the biochemical databases

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Phylogenetic tree of SLC25A39 homologs across model organisms