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Previous molecular approaches 12,25 and recent multi-locus approaches 8,9 also support the polyphyletic nature of Ea

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Esm1-CreERT2 -mediated loss of Itgb1 at P6 results in defective extension of tip cells in the Itgb1 i Esm1 KO mutants compaired to Itgb1 i Esm1 HET control littermates, resulting in blunt areas in the vascular plexus growing front (Supplementary Fig

Acknowledgements This work was supported by the Guangdong Basic and Applied Basic Research Foundation (No

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