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Description

Clinically significant fluid retention could theoretically alter the volume of distribution of apixaban, though no study has quantified this effect

Mahar, R

In terms of iron metabolism and homeostasis in immune cells, a study revealed that iron overload promotes abnormal differentiation of pathogenic T cells, including follicular helper T cells, by regulating DNA demethylation, thus exacerbating autoantibody production and the development of systemic lupus erythematosus (SLE) [26]