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10.4049/jimmunol.176.2.1046 78 MarosoM.BalossoS.RavizzaT.LiuJ.AronicaE.IyerA

It did not establish that participants had insomnia, and it did not demonstrate a validated improvement in sleep onset, total sleep time, sleep quality or daytime functioning

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Impaired synaptic plasticity and decreased excitability of hippocampal glutamatergic neurons mediated by BDNF downregulation contribute to cognitive dysfunction in mice induced by repeated neonatal exposure to ketamine

Some common issues that would be experienced pointing towards an issue would be: Clogging of nozzles Accelerated oxidation Growth of micro-organisms Fouling of the heat exchanger and its surfaces Reduction in pipe sizes, by the depositing of scale on the internal surfaces