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Corn, P

( Most NAFLD patients are obese and present a mild systemic inflammation, which hampers insulin signaling [insulin resistance (IR)], playing a relevant role in the pathomechanism of liver damage ( non-alcoholic fatty liver disease and proposed that of metabolic (dysfunction)associated fatty liver disease ( However, it has been found that hepatic lipid accumulation in NAFLD occurs mostly as relatively inert TGs droplets, and this is nowadays regarded as a protective rather than a deleterious mechanism, by impeding the storage of free fatty acids (FFAs), which are the actual harmful agents in this hepatopathy

Zorriehzahra et al

One of the livers primary functions is removing toxins from the body

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies