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Resveratrol mitigates lipopolysaccharide- and Abeta-mediated microglial inflammation by inhibiting the TLR4/NF-kappaB/STAT signaling cascade

This culminates in (1) axo-dendritic pathology coupled to loss of synaptic function, (2) impaired mitochondrial dynamics coupled with altered energy homeostasis, and (3) impaired dopamine metabolism, all of which contribute to further RNS imbalance

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A wide range of physiological properties has been reported following the intake of polyphenols in adequate amount such as antioxidant, anti-inflammatory, anti-diabetic, anti-obesity, cardioprotective, neuroprotective, anti-asthmatic, anxiolytic, antidepressant, antimicrobials, anticarcinogenic, to name a few (Ullah et al

Although specific biomarkers for ASD have not been unearthed, several studies suggest using genetic, proteomic, and metabolomics-related markers for diagnostic purposes [7]