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Then, on Monday, January 18th, exactly one week after her first dose, Brown says the area became itchy and irritated

Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways

The antibody-drug conjugate according to claim 1, wherein D is a moiety of formula (V)WhereinX is C or N, preferably N;R11 is selected from the group consisting of H, and C 1 -C 12 alkyl,L' is a bond or a linker, preferably selected from C 1 -C 12 alkylene, C 1 -C 12 heteroalkylene, C 3 -C 6 cycloalkylene, heterocyclylene having 5 to 10 ring atoms, arylene having 6 to 10 ring atoms, heteroarylene having 5 to 10 ring atoms, and any combination thereof, and Ring B is a heterocycloalkyl having 3 to 10 ring atoms, or a heteroaryl having 5 to 10 ring atoms, said heterocycloalkyl and heteroaryl being optionally substituted, preferably by one or more substituent selected from -OH, =O, C 1 -C 12 alkyl, C 1 -C 12 heteroalkyl, C 3 -C 6 cycloalkyl, heterocyclyl having 5 to 10 ring atoms, aryl having 6 to 10 ring atoms, heteroaryl having 5 to 10 ring atoms, -(C 1 -C 12 alkyl)-(C 3 -C 8 cycloalkyl), -(C 1 -C 12 alkyl)-(heterocycloalkyl having 3 to 10 ring atoms), -(C 1 -C 12 alkyl)-(heteroaryl having 5 to 10 ring atoms), -(C 1 -C 12 alkyl)-(aryl having 6 to 10 ring atoms), and -NR'R"

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As cells divide, these telomeres gradually shorten, leading to cellular aging and eventual cell death