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Mechanistically, these cells transduce complex molecular signals, such as aberrant activation of the NF-B and activator protein 1 (AP-1) pathways, into sustained proinflammatory and profibrotic phenotypes

Clinical trial design in ALS continues to advance, allowing for better measurement of changes in outcomes via patient stratification, identification of patients most likely to benefit from specific drug mechanisms, and methods for faster drug development and availability to patients

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Second, curcumin decreases the production of several inflammatory mediators like cytokines and chemokines