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& Finkel, T

Nature 193 , 381382 (1962)

1 Introduction Renal cell carcinoma (RCC) is a malignant tumor originating from the renal tubular epithelial cells, accounting for 90-95% of all kidney cancers ( The PI3K-AKT-mTOR signaling pathway functions as a central regulatory pathway governing cell survival, proliferation, metabolism, and angiogenesis ( Accordingly, from a systems biology perspective, this review integrates the genetic basis of RCC with the aberrant activation mechanisms of the PI3K-AKT-mTOR pathway, systematically dissects its network functions in metabolic reprogramming, angiogenesis, and the regulation of apoptosis and autophagy, and establishes its central hub role in RCC initiation and progression