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Novel pharmacological agents and interventions in myocardial IRI Targeting innate and adaptive immunity: NLRP3-, SGLT- and PARP-inhibitors NLRP3 inhibitors are emerging as a new class of immunomodulatory compounds with potential relevance across multiple inflammatory and cardiometabolic conditions, and their therapeutic potential continues to expand as increasing preclinical and translational evidence clarifies their mechanisms of action

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