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"There are allowances for doctors to make their own decisions backed up by robust evidence to prescribe unapproved products to their patients," the TGA's chief medical adviser Robyn Langham said

Inflammatory mediators of experimental colitis in rats

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Protease-sensitive pro-antibodies whose Fc or Fab regions are masked until exposure to tumor-specific proteases could also restrict MDSC blockade to the malignant niche, reducing systemic toxicity (199)