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Similarly, mitophagy enhancers (e.g., urolithin A) and metabolic regulators (e.g., nicotinamide riboside, metformin) have shown promising activity in cellular and animal models, but their therapeutic effects in human PD (mitochondrial dysfunction evolving over decades) are largely unknown [135,136,137,138]

It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and increases their thermodynamic stability

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This review highlights the unique potential of phytochemicals to advance the treatment of IC, offering opportunities to move beyond traditional therapies

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