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A large amount of ROS is generated during the mutual conversion of Fe 3+ and Fe 2+ through redox reactions, leading to tissue damage and ferroptosis (31)

(35) Conclusion GLP-1 receptor agonists are becoming integral to obesity and diabetes management, with significant implications for orthopedic surgery

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The reason for this divergent outcome may lie in a specific hydrogen-bonding network, Thr---Asp---H 2 O, that is present in the canonical PDO active site but missing in CstB (Fig