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High-dose folic acid supplementation results in significant accumulation of unmetabolized homocysteine, leading to severe oxidative stress in Caenorhabditis elegans

When the type of diabetes is uncertain or atypical, additional investigations including C-peptide levels and diabetes-specific autoantibodies (e.g., GAD antibodies) may be arranged to help clarify the diagnosis

Front Behav Neurosci (2018) 12:266

A deeper understanding of the potential interaction between genetic and environmental factors would be instrumental to deepen this debate, and for the development of preventive strategies for patients and their family members

Other enriched subsystems are N-glycan synthesis as well as degradation and glycolysis/gluconeogenesis