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It preserves alveolar bone density in patients experiencing age-related bone loss, accelerates bone graft healing timelines, and promotes systemic collagen turnover that benefits periodontal ligament and TMJ disc integrity

Currently, the integration of these two fields is not necessarily happening since (1) models are often trained from structures and data with little domain expert guidance

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This nuclear localization in elderly Leydig cells correlated with reduced expression of 3-HSD, a crucial enzyme for testosterone synthesis, suggesting a link between nuclear FOXO4 and age-related decline in testosterone production [2]