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Funding This work was fund by the project of CAMS Innovation Fund for Medical Sciences (2016-I2M-3-005)

Studies in Pink1 -deficient Drosophila and mouse models demonstrated that an early consequence of Pink1 deficiency is the disruption of complex I function, leading to mitochondrial membrane depolarization, increased sensitivity to apoptotic stress, and synaptic transmission deficits [90]

Interestingly, the BP pyrenyl ring system points towards the 5-direction of the modified strand (Fig

The addition dosage of theaflavins is based on previous research [17]

Ferroptotic cells release DAMPs (e.g., HMGB1, ATP) and oxidized lipids, which activate pro-inflammatory immune cells