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The first-of-its-kind metformin clinical trial targeting aging with metformin (TAME), currently in its initiation stage and is expected to recruit 3000 elderly adults, who will be chronically administered clinically relevant dosages Metformin over six years and assessed for effects on parameters and indications of aging

In in vitro cell experiments, it is widely used to verify the relationship between NNMT activity and cellular energy metabolism

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