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Although hypotheses such as the reactive species hypothesis involving oxygen and C-centred radicals or carbocations, and the heme (Fe) activation hypothesis (or heme model) are related, they are also different from each other

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Such assays require costly equipment, skilled personnel and strict validation

All the mice were housed under standard SPF conditions at the ACF

After knocking out the ZEB1 gene related to lipid uptake, aggregation, and migration, the sensitivity to ferroptosis and susceptibility to ferroptosis inducers was significantly increased, leading to drug-resistant cancer cell death [78, 98]