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When this was unclear, we considered a mortality rate higher than 5% (hospital mortality and if this was not reported we used ICU mortality or 28-day mortality) in the control group to be consistent with critical illness, c) intervention: parenteral GLN versus control (either isonitrogenous amino acid control) or placebo, d) study outcomes: must have included one of the following: mortality, ICU and hospital LOS, infectious complications, and other clinically important complications

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3.1.4.3 Strategies to bridge translational difficulties To improve clinical translatability, the following strategies are recommended: (1) Multi-species validation: mechanisms discovered in mice should be validated in rats, rabbits, or non-human primates

The authors of a study investigated the effects of GSH in nine patients with untreated early PD

362 In SLE, neutrophil-derived NETs can also suppress Treg differentiation by activating the TLR4 signaling pathway in nave CD4 T cells through S100A10