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An accumulation of lactate to dangerous levels ( lactic acidosis ) can occur when metformin is taken by patients with other conditions resulting metabolic acidosis (liver disease, heart failure, sepsis, alcohol abuse), or kidney disease (as indicated by elevated creatinine levels) because metformin is eliminated by renal excretion) (He & Wondisford, 2015

After rinsing the slides were quickly dipped (510 times) in an alkaline ethanol solution (1% sodium hydroxide in 50% ethanol) and washed again in water

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