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While some mutations may result in alleles that confer greater accumulation or tolerance to toxic heavy metals that could be beneficial, we expect that most mutations that result in excess uptake of heavy metals to be deleterious

doi: 10.1155/2013/687197 3 ThomfordNESenthebaneDARoweAMunroDSeelePMaroyiAet al

Mov Disord (2008) 23:1055.10.1002/mds.21945 116 GradyEFSechiLAGriffinCASchambelanMKalinyakJE

Primers and plasmid lists are provided in the Supplementary Information