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Further findings (102) reveal that iron overload leads to the increase of MMP and the accumulation of lipid peroxide by affecting GSH and fatty acid cycle, which further promotes the activation of osteoclasts and apoptosis of osteoblasts, leading to increased bone resorption and decreased bone formation

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Physical trauma, exposure to heavy metals, mold toxins, and bacterial and viral infections damage cellular, mitochondrial, and DNA membranes

[DOI] [PubMed] [PMC] Morrone CD, Raghuraman R, Hussaini SA, Yu WH

10.1016/j.tcb.2018.07.006 5