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Ryland GL, Hunter SM, Doyle MA, Caramia F, Li J, Rowley SM, et al

The combination therapy of metformin and CDDP weakens ERK-mediated phosphorylation of NRF2, enhances its polyubiquitination, and promotes its proteasomal degradation, thereby significantly reducing the levels of NRF2 in A549/DDP and H838 NSCLC cells, promoting ROS-mediated apoptosis