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Clinical research and translational applications Current trends in clinical trials for aging interventions Senolytic agents in the clinical stage Several promising strategies against aging have entered clinical trials with preliminary evidence of safety and efficacy in humans (Table 3)

Long R3 IGF-1, Long Arginine 3-IGF-1, LR3-IGF-1 20-30 hours (vs 12-15 minutes for native IGF-1) IGF-1 LR3 (Long R3 IGF-1) is a modified insulin-like growth factor 1 with an arginine substitution at position 3 and a 13-amino acid N-terminal extension