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Membrane ruffling Dynamic, actin-rich protrusions of the plasma membrane that initiate macropinocytosis in response to external stimuli such as growth factors or oncogenic signals

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Chemical Information Molecular Weight 5676.60 Formula C 235 H 362 N 76 O 67 S 11 Sequence Ser-Ser-Arg-Arg-Cys-Val-Arg-Leu-His-Glu-Ser-Cys-Leu-Gly-Gln-Gln-Val-Pro-Cys-Cys-Asp-Pro-Cys-Ala-Thr-Cys-Tyr-Cys-Arg-Phe-Phe-Asn-Ala-Phe-Cys-Tyr-Cys-Arg-Lys-Leu-Gly-Thr-Ala-Met-Asn-Pro-Cys-Ser-Arg-Thr-NH2 (Disulfide bridge: Cys1-Cys4

These results suggest that high-glucose conditions do not substantially alter B12 availability in animals

The authors attributed this discrepancy to the small sample size and suggested that it may be partly due to a delayed response of maternal plasma glucose concentrations, which are stable between 1:00 a.m