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In PCOS granulosa cells, elevated phosphorylation of the pro-apoptotic protein BAX, coupled with suppressed phosphorylation of the anti-apoptotic protein BCL-2, enhances mitochondrial pathway apoptosis, accelerating follicular atresia ( 3.6 Chronic low-grade inflammation Chronic low-grade inflammation have been identified as a central component in the pathogenesis of PCOS, rather than mere accompanying phenomena

2017;67(658):e32935

The Favorable Effects of Garlic Intake on Metabolic Profiles, Hs-CRP, Biomarkers of Oxidative Stress and Pregnancy Outcomes in Pregnant Women at Risk for Pre-Eclampsia: Randomized, Double-Blind, Placebo-Controlled Trial. The Journal of Maternal-Fetal & Neonatal Medicine , vol

HMP shunt and cancer: Several studies have investigated the role of the HMP shunt in cancer metabolism

In some embodiments, the antibodies encompassed by the present invention can be humanized antibodies