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In conclusion, BRAF V600E is a common kinase activating alteration in human cancer and in CNS with high prevalence in pLGG, whereby patients with BRAF V600E altered tumors are routinely, successfully treated with molecular targeted therapy (BRAF inhibition)

For instance, mitochondrial-targeted zinc-finger nucleases (mtZFNs) and transcription activator-like effector nucleases (mtTALENs) are engineered to bind specific mtDNA mutation sites

Heterologous prime-boost vaccine regimens combining SpFN with Johnson & Johnsons adenoviral vectored vaccine Ad26.COV2.S induced strong nAb and T-cell responses that protected mice from heterologous Omicron BA.5 challenge [130]

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