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Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

Targeting metabolic vulnerabilities in specific macrophage subsets, such as limiting ferroportin-mediated iron export in M2 TAMs or enhancing ACSL4-dependent lipid peroxidation in inflammatory TAMs, may shift the TME toward a ferroptosis-permissive state

Thats where things get complicated

Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study

Ascorbate plus buformin in AML: A metabolic targeted treatment